منابع مشابه
Positive Feedback Promotes Oscillations in Negative Feedback Loops
A simple three-component negative feedback loop is a recurring motif in biochemical oscillators. This motif oscillates as it has the three necessary ingredients for oscillations: a three-step delay, negative feedback, and nonlinearity in the loop. However, to oscillate, this motif under the common Goodwin formulation requires a high degree of cooperativity (a measure of nonlinearity) in the fee...
متن کاملModeling genetic switches with positive feedback loops.
In this paper, we develop a new methodology to design synthetic genetic switch networks with multiple genes and time delays, by using monotone dynamical systems. We show that the networks with only positive feedback loops have no stable oscillation but stable equilibria whose stability is independent of the time delays. In other words, such systems have ideal properties for switch networks and ...
متن کاملEvolution of Feedback Loops in Oscillatory Systems
Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case studies. Using a simple core architecture (transcription, phosphorylati...
متن کاملEngineering Self-Adaptive Systems through Feedback Loops
To deal with the increasing complexity of software systems and uncertainty of their environments, software engineers have turned to self-adaptivity. Self-adaptive systems are capable of dealing with a continuously changing environment and emerging requirements that may be unknown at design-time. However, building such systems cost-effectively and in a predictable manner is a major engineering c...
متن کاملDeconvolving Feedback Loops in Recommender Systems
Collaborative filtering is a popular technique to infer users’ preferences on new content based on the collective information of all users preferences. Recommender systems then use this information to make personalized suggestions to users. When users accept these recommendations it creates a feedback loop in the recommender system, and these loops iteratively influence the collaborative filter...
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ژورنال
عنوان ژورنال: Journal of Agriculture, Food Systems, and Community Development
سال: 2013
ISSN: 2152-0801
DOI: 10.5304/jafscd.2013.033.007